International Journal of Modern Science and Technology

INDEXED IN 

ISSN 2456-0235

​​​​​​​June 2020, Vol. 5, No. 6, pp. 149-156. 

​​​Effect of Methanolic Extract of Chromolaena odorata Leaves on Lipid Profile, Hmgco-A Reductase Enzyme Activity and haematological Activity of P407 induced Hyperlipidemic Albino Rats

A. Mukhtar¹*, I. Bawa¹, G. O. Ogo²
¹Department of Biochemistry Federal University of Agriculture Makurdi Benue State, Makurdi, Nigeria.

²Department of Biochemistry Benue State University Makurdi, Makurdi, Nigeria.

​​​*Corresponding author’s e-mail: mukkyabu@gmail.com

​Abstract

​The research was aimed at determining the effect of Chromolaena odorata on lipid profile, HMGCO-A reductase enzyme activity and Haematogical indices of P407 induced hyperlipidemic albino rats. The Lipid profile, HMGCO-A enzymes activity and Haematological indices of rat blood were measured. It was observed that after induction with poloxamer 407, there was an increase in the lipid profile activity from 133.30±33 to 154.23±4.55, 104.10±1.23 to 120.23±3.45. An induction with poloxamer 407 led to an increase in the HMG COA enzyme activity from 1.33±0.4 to 3.41±0.50 also there was an increase in the WBC count from 12.46±0.23 to 18.17±1.23 while there was a reduction in PCR count from 23.42±0.45 to 15.2±0.01. The values were statistically significant different down the groups. The findings of the present study demonstrated that poloxamer407 induced hyperlipidemia is associated with a change in Lipid profile, HMG-COA reductase enzyme activity and Haematological parameters which were ameliorated by treatment with C. odorata. The effect observed could be as a result of interactions between supplements biological active constituents and endogenous antioxidant system in the experimental animal model.

Keywords:Chromolaena odorata; Poloxamer 407; Methanolic extract; Hyperlidemia; HMGCO-A reductase; Haematological parameters.

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