ISSN 2456-0235

International Journal of Modern Science and Technology

INDEXED IN 

​​​​​​​May 2020, Vol. 5, No. 5, pp. 128-136. 

​​​Effect of methanolic crude and purified root extracts of Moringa oleifera on Liver enzymes activities, Kidney function and Histopathology in poloxamer 407-induced hyperlipidemic albino rats

Inalegwu Bawa, Itodo Matthew Ocheleka*, Ogli Itolo
Department of Biochemistry, Federal University of Agriculture Makurdi, Benue State, Nigeria.

​​​*Corresponding author’s e-mail: ocheleka1@gmail.com

​Abstract

​The research was aimed  To  evaluate  the  effect  of  methanolic  Root  Extract  of  Moringa  oleifera  on  Liver enzymes activities, Kidney function and  Histopathology in  Poloxamer  407 induced Hyperlipidemic Albino  rats. albino rats were grouped into 8; Group 1: Normal control given only food and water, Group 2: Hyperlipidemic control not treated, Group 2 to 8 were induced with Poloxamer 407 1000 mg/Kg body weighty, however group 3 was treated with standard drugs atorvastatin (10 mg/kg). Group 4 treated with crude root extract (200 mg/kg) of Moringa oleifera and group 5 to 8 were treated with purified fraction from column chromatography. The study  showed  Methanolic root extract at  200 mg/kg  body  weight  significantly  (p>0.05) decrease Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Alkaline phosphatase (ALP), Creatinine, Urea, of the treated groups, and extract of moringa oleifera has demonstrated strong anti-lipidemic and hepatoprotective tendency. The work thus provides the phytotherapeutic potential of methanolic root extract of Moringa oleifera that may be needed by scientists and researchers in nutraceutical industry.

Keywords:Moringa oleifera; Poloxamer 407; Enzymes liver activities; Kidney function; Histopathology.

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