ISSN 2456-0235

International Journal of Modern Science and Technology

INDEXED IN 

​​​​​​​April 2020, Vol. 5, No. 4, pp. 117-123. 

​​​Effect of Methanolic Extract of Ginger (Zingiber officinale) on Lipids Profile, Liver Enzymes Activities and Kidney Functions of P407 induced Hyperlipidemic Albino Rats

E. U. Emmanuel¹*, I. Bawa¹, G. O. Ogo²
¹Department of Biochemistry Federal University of Agriculture Makurdi Benue State, Nigeria.

²Department of Biochemistry, Benue State University Makurdi, Nigeria.

​​​*Corresponding author’s e-mail: emmanuelakwa24@gmail.com

​Abstract

​The aim of the research was to investigate the effect of methanolic extract of ginger (Zingiber officinale) on the liver enzymes activities, lipid profile, kidney function in P407 induce hyperlipidemic albino rats. Liver enzymes, lipid profile and kidney function activity of rat blood were measured. Liver enzymes activity increases from 15.23±2.22 to 110.30±3.22 and from 20.45±4.5 to 40.11±6.7 in AST and ALT enzymes respectively, a decrease was observed from 120.12±1.22 to 92.12±5.6 in the ALP enzymes activity. An increase in the lipid profile from 133.30 ± 33, 154.23±4.55, 104.10±1.23 ± 120.23 ± 4.5C and from 92.34±3.67 to 113.34±5.67 in TG, LDL and Cholesterol level. However, a significant decrease was observed in the HDL from 123.45 ± 3.4 to 80.01 ± 2.0­. An induction with poloxamer 407 led to an increase from 35.34±3.35 to 55.56±1.34 in Urea and from 1.33±0.45 to 4.54±0.50 in creatinine level respective. The findings of the study demonstrated that poloxamer 407 induced hyperlipidemia is associated with elevated lipids profile, liver enzymes and kidney disturbance, which were ameliorated by treatment with ginger.

Keywords: Zingiber officinale; Poloxamer; Methanolic extract; Lipid profile; Kidney function activity; Hyperlipidemia.

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